Effect of PEG Corona Lengths on MR Relaxivity and Off-resonance Saturation Sensitivity of Superparamagnetic Polymeric Micelles

Off-resonance saturation MRI of superparamagnetic nanoprobes: theoretical models and experimental validations.

Off-resonance saturation (ORS) is a new magnetic resonance imaging (MRI) method that has shown greatly improved contrast sensitivity for the detection of cancer-specific biomarkers by superparamagnetic nanoprobes in vivo. However, quantitative understanding of the ORS contrast mechanism and its dependence on the structural parameters of superparamagnetic nanoprobes are still lacking. Here we pr...

Effect of Corona Lengths on Magnetic Resonance Imaging Sensitivity of Superparamagnetic Polymeric Micelles

In Vivo Off Resonance Saturation Magnetic Resonance Imaging of αvβ3-Targeted Superparamagnetic Nanoparticles

Magnetic resonance imaging (MRI) is a powerful clinical imaging technique that allows for non-invasive tomographic visualization of anatomic structures with high spatial resolution and soft tissue contrast. However, its application in molecular imaging of cancer has been limited due to the lack of sensitivity and detection accuracy in identifying the biological processes of this disease. Recent...

Synthesis and in vitro experiments of carcinoma vascular endothelial targeting polymeric nano-micelles combining small particle size and supermagnetic sensitivity

Objective: To construct carcinoma vascular endothelial-targeted polymeric nanomicelles with high magnetic resonance imaging (MRI) sensitivity and to evaluate their biological safety and in vitro tumor-targeting effect, and to monitor their feasibility using clinical MRI scanner. Method: Amphiphilic block copolymer, poly(ethylene glycol)-b-poly(ε-caprolactone) (PEG-PCL) was synthesized via the r...

In vivo Off-Resonance Saturation Magnetic Resonance Imaging of AvB3-Targeted Superparamagnetic Nanoparticles

Magnetic resonance imaging is a powerful clinical imaging technique that allows for noninvasive tomographic visualization of anatomic structures with high spatial resolution and soft tissue contrast. However, its application in molecular imaging of cancer has been limited by the lack of sensitivity and detection accuracy in depicting the biochemical expression of these diseases. Here, we combin...